Recent insights into the development of therapeutics against coronavirus diseases by targeting N protein
Identifieur interne : 001597 ( Main/Exploration ); précédent : 001596; suivant : 001598Recent insights into the development of therapeutics against coronavirus diseases by targeting N protein
Auteurs : Chung-Ke Chang [Taïwan] ; Shou-Chen Lo [Taïwan] ; Yong-Sheng Wang [Taïwan] ; Ming-Hon Hou [Taïwan]Source :
- Drug Discovery Today [ 1359-6446 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Infections à coronavirus, Protéines nucléocapside.
- pharmacologie : Antiviraux.
- traitement médicamenteux : Infections à coronavirus.
- usage thérapeutique : Antiviraux.
- Animaux, Humains, Protéines nucléocapside.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Nucleocapsid Proteins.
- chemical , metabolism : Nucleocapsid Proteins.
- chemical , pharmacology : Antiviral Agents.
- chemical , therapeutic use : Antiviral Agents.
- drug therapy : Coronavirus Infections.
- metabolism : Coronavirus Infections.
- Animals, Humans.
Abstract
Coronavirus nucleocapsid proteins are appealing drug targets against coronavirus-induced diseases. A variety of compounds targeting the coronavirus nucleocapsid protein have been developed. Many of these compounds show potential antiviral activity.
Url:
DOI: 10.1016/j.drudis.2015.11.015
PubMed: 26691874
PubMed Central: 7108309
Affiliations:
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sortKey="Lo, Shou Chen" sort="Lo, Shou Chen" uniqKey="Lo S" first="Shou-Chen" last="Lo">Shou-Chen Lo</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227</wicri:regionArea><wicri:noRegion>Taichung 40227</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yong Sheng" sort="Wang, Yong Sheng" uniqKey="Wang Y" first="Yong-Sheng" last="Wang">Yong-Sheng Wang</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227</wicri:regionArea><wicri:noRegion>Taichung 40227</wicri:noRegion></affiliation></author><author><name sortKey="Hou, Ming Hon" sort="Hou, Ming Hon" uniqKey="Hou M" first="Ming-Hon" last="Hou">Ming-Hon Hou</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227</wicri:regionArea><wicri:noRegion>Taichung 40227</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0015">Biotechnology Center, National Chung Hsing University, Taichung 40227, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Biotechnology Center, National Chung Hsing University, Taichung 40227</wicri:regionArea><wicri:noRegion>Taichung 40227</wicri:noRegion></affiliation></author></analytic><series><title level="j">Drug Discovery Today</title><idno type="ISSN">1359-6446</idno><idno type="eISSN">1878-5832</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Antiviral Agents (therapeutic use)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (metabolism)</term><term>Humans</term><term>Nucleocapsid Proteins (chemistry)</term><term>Nucleocapsid Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (pharmacologie)</term><term>Antiviraux (usage thérapeutique)</term><term>Humains</term><term>Infections à coronavirus (métabolisme)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Protéines nucléocapside ()</term><term>Protéines nucléocapside (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Nucleocapsid Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Nucleocapsid Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Infections à coronavirus</term><term>Protéines nucléocapside</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Protéines nucléocapside</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Coronavirus nucleocapsid proteins are appealing drug targets against coronavirus-induced diseases.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">A variety of compounds targeting the coronavirus nucleocapsid protein have been developed.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Many of these compounds show potential antiviral activity.</p></list-item></list></p></div></front><back><div1 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Wongyanin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bolles, Gt M" uniqKey="Bolles ">>M. Bolles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adedeji, A O" uniqKey="Adedeji A">A.O. Adedeji</name></author><author><name sortKey="Sarafianos, S G" uniqKey="Sarafianos S">S.G. Sarafianos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R. Hilgenfeld</name></author><author><name sortKey="Peiris, M" uniqKey="Peiris M">M. Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graham, R L" uniqKey="Graham R">R.L. Graham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Omrani, A S" uniqKey="Omrani A">A.S. Omrani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R. Hilgenfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keum, Y S" uniqKey="Keum Y">Y.S. Keum</name></author><author><name sortKey="Jeong, Y J" uniqKey="Jeong Y">Y.J. Jeong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y S" uniqKey="Wang Y">Y.S. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Chang, Chung Ke" sort="Chang, Chung Ke" uniqKey="Chang C" first="Chung-Ke" last="Chang">Chung-Ke Chang</name></noRegion><name sortKey="Hou, Ming Hon" sort="Hou, Ming Hon" uniqKey="Hou M" first="Ming-Hon" last="Hou">Ming-Hon Hou</name><name sortKey="Hou, Ming Hon" sort="Hou, Ming Hon" uniqKey="Hou M" first="Ming-Hon" last="Hou">Ming-Hon Hou</name><name sortKey="Lo, Shou Chen" sort="Lo, Shou Chen" uniqKey="Lo S" first="Shou-Chen" last="Lo">Shou-Chen Lo</name><name sortKey="Wang, Yong Sheng" sort="Wang, Yong Sheng" uniqKey="Wang Y" first="Yong-Sheng" last="Wang">Yong-Sheng Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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